Oncobox Tests

Oncobox:Integral Test
DNA and RNA of over 2,000 genes from major molecular pathways of a patient’s tumor are analyzed. The Oncobox:Integral Test algorithm is applied to distinguish which molecular targets are the most crucial, and the patient’s oncologist receives a report with drug options ranked by expected effectiveness.

Here are the steps in more detail:

Step 1: Tumor specimen is sent to Oncobox. For the analysis, we need a slice of a formalin-fixed paraffin-embedded (FFPE) block of a tumor biopsy or fragment of a tumor removed after surgery. The FFPE blocks are normally kept in the hospitals where the biopsy or surgery procedures were perfomed.

Step 2: Based on the tumor data, Oncobox:Integral Test analyzes DNA and RNA signatures of over 2,000 genes that are included in major tumor molecular pathways. Expression of individual molecular targets is analyzed, along with activation of intracellular pathways.

Step 3: Basing on its unique knowledge dabase, Oncobox:Integral Test simulates the effect of over 140 target drugs on the patient’s cancer.

Step 4: Drugs are ranked on possible effectiveness, and a report is sent to the patient’s oncologist to assist with treatment decisions.

Benefits of Oncobox:Integral test

  • Gives doctors an efficient data-driven approach to finding the right cancer drug, instead of relying on trial and error
  • Our test analyzes mutation and gene expression signatures included in over 700 major tumor molecular pathways.
  • High-throughput molecular analysis by CLIA/CAP certified laboratory
  • Comprises 140 FDA approved cancer drugs involved in over 800 treatment protocols
  • All major solid tumors eligible
  • Comprises full clinical trials annotation for top-rated drugs

    The following drug types are comprised:

    1. Target low molecular mass inhibitors (nibs)
    2. Hormones
    3. Hormone inhibitors or antagonists
    4. Retinoids
    5. Rapamycin analogues
    6. Proteasome inhibitors (mibs)
    7. Anti-VEGF drugs
    8. Target monoclonal antibodies (mabs)
    9. Killer antibodies (killer mabs)
    10. Microtubule polymerization inhibitors
    11. Histone deacetylase inhibitors
    12. Alkylating agents
    13. Immunotherapeutic target antibodies (anti-PD1, -PD1L1, -CTLA4)
    14. Poly ADP ribose polymerase inhibitors

    The research underlying the Oncobox:Integral Test is available in Our Research section.

    Companion Diagnostics
    We are also developing companion diagnostics for several drugs currently on the market to help doctors decide if one specific drug they may be considering is right for their patient. One example is the Oncobox:Sorafenib test, which can help doctors determine if the drug Nexavar (Sorafenib) may be effective for patients with cancers of the kidney, liver, and thyroid.

    Tumor types eligible for Oncobox tests

    1. Anal Cancer
    2. Bile Duct Cancer
    3. Bladder Cancer
    4. Bone Cancer
    5. Brain/CNS Tumors
    6. Breast Cancer
    7. Breast Cancer In Men
    8. Cancer of Unknown Primary Origin
    9. Cervical Cancer
    10. Colorectal Cancer
    11. Endometrial Cancer
    12. Esophagus Cancer
    13. Ewing Family Of Tumors
    14. Eye Cancer
    15. Gallbladder Cancer
    16. Gastrointestinal Carcinoid Tumors
    17. Gastrointestinal Stromal Tumor (GIST)
    18. Hodgkin Disease
    19. Kaposi Sarcoma
    20. Kidney Cancer
    21. Laryngeal and Hypopharyngeal Cancer
    22. Liver Cancer
    23. Lung Cancer – Non-Small Cell
    24. Lung Cancer – Small Cell
    25. Carcinoid Tumor
    26. Malignant Mesothelioma
    27. Nasal Cavity and Paranasal Sinus Cancer
    28. Nasopharyngeal Cancer
    29. Neuroblastoma
    30. Non-Hodgkin Lymphoma
    31. Oral Cavity and Oropharyngeal Cancer
    32. Osteosarcoma
    33. Ovarian Cancer
    34. Pancreatic Cancer
    35. Penile Cancer
    36. Pituitary Tumors
    37. Prostate Cancer
    38. Retinoblastoma
    39. Rhabdomyosarcoma
    40. Salivary Gland Cancer
    41. Sarcomas
    42. Skin Cancer – Basal and Squamous Cell
    43. Skin Cancer – Melanoma
    44. Skin Cancer – Merkel Cell
    45. Small Intestine Cancer
    46. Stomach Cancer
    47. Testicular Cancer
    48. Thymus Cancer
    49. Thyroid Cancer
    50. Uterine Sarcoma
    51. Vaginal Cancer
    52. Vulvar Cancer

    Sample reports
    Sample test report for Lung cancer
    Some details have been removed from the sample reports to protect patient confidentiality.